AI-Enabled Biotech
Why we invest
Combining scientific insights, wet lab innovation, applied AI, and advanced analytics promises to revolutionize life sciences, including discovery, diagnostics, and drug development. The newest generation of technology in life science is unlocking novel approaches to cure intractable diseases and generating drugs with increased precision and effectiveness. New tech-enabling layers are supercharging scientists to accelerate early-stage discoveries and lowering barriers to clinical breakthroughs. Madrona partners with leading research institutions, like the UW’s Institute of Protein Design, the Fred Hutch Cancer Center, and Caltech, to help researchers translate their innovations into real-world impact. With decades of experience investing in AI/ML and working alongside partners from pharma to tech hyperscalers, Madrona helps founders bring their vision for a brighter future to life.
Nautilus Bio’s
Sujal Patel and Parag Mallick
on the proteome 
A-Alpha Bio’s
David Younger
on advancing drug discovery and the role of company culture 
Terray’s
Jacob Berlin
on why data is the difference for AI-driven drug development AI-Enabled Biotech
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Envisagenics is an Artificial Intelligence-driven biotechnology company that focuses on the discovery of novel RNA splicing variants that cause cancer and other genetic diseases. Its principal technology is the SpliceCore® discovery platform. The platform re-envisions the human genome with a validated exon-centric approach, combined with machine learning algorithms and high-performance computing. It is up to 250 times more likely to discover novel targets than gene-centric discovery tools. Using innovative technology and RNA analysis expertise, Envisagenics accelerates the development of highly specific therapeutics that modulate RNA splicing events that drive pathogenesis of oncology, neurodegenerative, and metabolic disorders.Initial Investment2018Envisagenics is an Artificial Intelligence-driven biotechnology company that focuses on the discovery of novel RNA splicing variants that cause cancer and other genetic diseases. Its principal technology is the SpliceCore® discovery platform. The platform re-envisions the human genome with a validated exon-centric approach, combined with machine learning algorithms and high-performance computing. It is up to 250 times more likely to discover novel targets than gene-centric discovery tools. Using innovative technology and RNA analysis expertise, Envisagenics accelerates the development of highly specific therapeutics that modulate RNA splicing events that drive pathogenesis of oncology, neurodegenerative, and metabolic disorders. -
Based in Seattle, Washington, Nautilus is a development stage life sciences company creating a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus’ mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit www.nautilus.bioInitial Investment2018Based in Seattle, Washington, Nautilus is a development stage life sciences company creating a platform technology for quantifying and unlocking the complexity of the proteome. Nautilus’ mission is to transform the field of proteomics by democratizing access to the proteome and enabling fundamental advancements across human health and medicine. To learn more about Nautilus, visit www.nautilus.bioFoundersSujal Petal
Parag MallickInvestment JourneyPublic June 2021
NASDAQ: NAUTInitial Investment2018 -
Ovation is a next-generation clinical informatics company.Initial Investment2019Ovation is a next-generation clinical informatics company. -
Proof is a startup working to make powerful CRISPR-based molecular testing affordable and accessible to everyoneInitial Investment2020Proof is a startup working to make powerful CRISPR-based molecular testing affordable and accessible to everyoneFoundersFeng Zhang
Jonathan Gootenberg
Omar Abudayyeh
Siddharth ShenaiInvestment JourneyAcquired by Ginkgo Bioworks
2024Initial Investment2020 -
TwinStrand Biosciences is a Seattle genomics company building a platform around Duplex Sequencing, a proprietary process that helps physicians, patients and drug researchers make life saving decisions faster based on DNA data.Initial Investment2019TwinStrand Biosciences is a Seattle genomics company building a platform around Duplex Sequencing, a proprietary process that helps physicians, patients and drug researchers make life saving decisions faster based on DNA data. -
Vilya is an AI enabled biotech company leveraging advanced computational approaches to design novel macrocycles with atomic-level accuracy and enhanced drug-like properties.Initial Investment2024Vilya is an AI enabled biotech company leveraging advanced computational approaches to design novel macrocycles with atomic-level accuracy and enhanced drug-like properties.